Basement membrane proteoglycans and development
نویسندگان
چکیده
منابع مشابه
Isolation of two forms of basement membrane proteoglycans.
Sequential extractions of the basement membrane producing Engelbreth-Holm-Swarm tumor yielded heparan sulfate proteoglycans with different size core proteins, but the same size heparan sulfate side chains. Saline, a nondenaturing solvent, extracted a small high density proteoglycan with a heterodisperse core protein of Mr = 95,000-130,000 whereas subsequent extraction with 7 M urea, a denaturin...
متن کاملGlomerular basement membrane proteoglycans are derived from a large precursor
The basement membrane heparan sulfate proteoglycan produced by the Englebreth-Holm-Swarm (EHS) tumor and by glomeruli were compared by immunological methods. Antibodies to the EHS proteoglycan immunoprecipitated a single precursor protein (Mr = 400,000) from [35S]methionine-pulsed glomeruli, the same size produced by EHS cells. These antibodies detected both heparan sulfate proteoglycans and gl...
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Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional homology with numerous extracellular matrix proteins, growth factors and surface receptors. They mainly carry heparan sulfate side chains and these c...
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Collagen type XV and XVIII are proteoglycans found in the basement membrane zones of endothelial and epithelial cells, and known for their cryptic anti-angiogenic domains named restin and endostatin, respectively. Mutations or deletions of these collagens are associated with eye, muscle and microvessel phenotypes. We now describe a novel role for these collagens, namely a supportive role in leu...
متن کاملBiosynthesis of stromal matrix proteoglycans and basement membrane components by human corneal fibroblasts.
The proteoglycans produced by intact human corneas and corneal cells in culture were compared by characterizing the biosynthetically radiolabeled proteoglycans and by using antibodies to detect their core proteins. Organ cultures of corneas primarily produce a keratan sulfate proteoglycan (KSPG) and a chondroitin and dermatan sulfate proteoglycan (decorin). Immunostaining with antibodies specif...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1993
ISSN: 0085-2538
DOI: 10.1038/ki.1993.14